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Additionally, analyses of the erythroleukemia cell line K562 indicate that FTH1 expression might prevent ROS-induced protein misfolding (74) and ROS-induced activation of the HIF1A/CXCR4 pathway leading to an epithelial-to-mesenchymal transition (EMT)-like phenotype (75)

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Furthermore there is also some limited and inconsistent evidence that changes in transporter activity may contribute to the reductions in UA seen in PD and these are reviewed below