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Tirzepatide vs Semaglutide: Side Effects Like all GLP-1based therapies, both Tirzepatide and Semaglutide share a similar side effect profile, largely related to gastrointestinal tolerance

In studies, patients lost up to 15-20% of their body weight* using branded GLP-1 medication

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However, once you reconstitute semaglutide by adding bacteriostatic water, the clock starts ticking at roughly the same rate as a pre-mixed liquid formulation