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Menzies SW, Liyanarachchi S, Coates E, Smith A, Cooke-Yarborough C, Lo S, et al

Distinguishing between these presentations is clinically important because management strategies differ substantially

ARA-290 (cibinetide) for neuropathy: the clinical trial peptide If BPC-157 represents the strongest preclinical evidence for peptide-based nerve repair, ARA-290 represents the strongest clinical evidence

Further investigations are needed to determine the value of H3K27me3 as a predictive marker for establishing sensitivity to epigenetic-based therapies (EZH2 inhibitors, BRD4 targeted therapies) in tumors such as malignant peripheral nerve sheath tumor and melanoma