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5 This article was written by McKayla Narveson, PharmD Candidate in collaboration with Eric Christianson, PharmD, BCPS, BCGP 10 Commandments of Polypharmacy Webinar based on my experiences in clinical practice Vaqar S, Shackelford KB

References SURMOUNT-5 head-to-head trial (NEJM, May 2025) summary via American College of Cardiology: SURPASS-2 primary publication (NEJM, 2021): Eli Lilly SURMOUNT-1 results announcement (NEJM data): Insights into the Mechanism of Action of Tirzepatide (PMC narrative review): Tirzepatide is an imbalanced and biased dual GIP/GLP-1 receptor agonist (PMC): SURMOUNT-5 GI tolerability / discontinuation data (Applied Clinical Trials, tctmd, DiabetesontheNet coverage): SURMOUNT-1 to -4 GI tolerability (Rubino 2025, Diabetes Obesity & Metabolism): Community sentiment context Reddit GLP-1 side-effect analysis and comparative meta-analyses (PMC): Research Use Only Notice: The content on this page is provided for informational and educational purposes only

Fang EF, et al

In the Carmina study, 33% of participants experienced morning nausea, and about 7% dealt with occasional vomiting