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The concomitant administration of -tocotrienol has demonstrated an increased efficacy of gemcitabine (88), and a phase I study on pancreatic cancer patients was conducted with escalating doses of -tocotrienol in the 2 weeks before surgery (91)

Amato, A., Baldassano, S., Liotta, R., Serio, R

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In animal models it repaired cognitive deficits at extraordinarily low doses but no human trials of any kind have been published, and its long-term safety is entirely unknown