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Under hypoxic conditions, HIF-1 orchestrates a metabolic shift that favors lipid uptake, synthesis, and storage while modulating fatty acid oxidation in a context-dependent manner (77, 111)

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Just like we dont consider and/or for the four pillars of guideline-directed medical therapy for heart failure with reduced ejection fraction, we shouldnt parcel out these two therapeutic optionsit should be both. Setting expectations with your patients regarding injection practices, side effects, and expected benefits can go a long way toward improving the patient experience with GLP-1 RAs