Compounded drugs should only be used in patients whose medical needs cannot be met by an FDA-approved drug
After taking patients' other risk factors for the condition into account, such as high blood pressure and obstructive sleep apnea, use of semaglutide was associated with a more than four times higher risk of NAION in those receiving it for diabetes and a more than seven times higher risk in patients taking it for obesity
This low original dose reduces the risk of side effects while your body adapts to the medication
FDA approves new drug treatment for chronic weight management, first since 2014, Food and Drug Administration (2021) Once-weekly semaglutide in adults with overweight or obesity, New England Journal of Medicine (2021) Updates about Wegovy, Novo Nordisk (2024) Medications containing semaglutide marketed for type 2 diabetes or weight loss, FDA (2024) Drug shortages, Food and Drug Administration (2024) Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension, Diabetes, Obesity & Metabolism (2022) FDA approves Lillys Mounjaro (tirzepatide) injection, the first and only GIP and GLP-1 receptor agonist for the treatment of adults with type 2 diabetes, Lilly Investors (2022) FDA approves new medication for chronic weight management, Food and Drug Administration (2023) FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize, Food and Drug Administration (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice
