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Contrarily, other work has shown that 10 weeks of RT (1-3 sets of 8 repetitions at 75% 1RM, 3 times per week) (Pereira et al., 2013) and 16 weeks of a multicomponent exercise paradigm (2 sets of 6-8 repetitions, 2 times per week) (Vaughan et al., 2014) were both sufficient to increase basal plasma BDNF in otherwise healthy elderly adults

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Thus, all three of the main UA transporters may contribute to the brain concentrations of UA through their action at the blood-brain barrier, although ABCG2 is thought to have the greatest effect, probably acting to remove UA from brain to blood 45