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Significant metabolites were identified based on p-value adjustment done by multiple testing at a false discovery rate (FDR) threshold of 0.25

If approved for obesity in April 2026, orforglipron would initially be marketed under a single indication, with the diabetes indication expected to follow approximately 12-18 months later

Challenges with Manufacturing and Supply of Obesity Drugs High Demand and Shortages: The surging demand for obesity drugs like Novo Nordisks Wegovy and Ozempic (semaglutide) and Eli Lillys Mounjaro (tirzepatide) and Trulicity (dulaglutide) has led to significant shortages

And Zepbound returns as a preferred option on October 1, 2026, after Caremark had dropped it last year