cons of glp 1 Weight loss Medications & Lipedema Pros & cons of GLP-1

doi: 10.1016/j.fertnstert.2018.06.036 45 KyrgiouM.MoscickiA

In STEP 1 [1] , the largest trial with 1,961 participants [1] , patients receiving semaglutide 2.4 mg weekly achieved an average weight loss of 14.9% over 68 weeks, compared to 2.4% with placebo (Wilding et al., NEJM, 2021)

Furthermore, some NGPs release extracellular vesicles and other bioactive metabolites that communicate with immune, epithelial, hepatic, and neural tissues, suggesting that their benefits may arise as much from postbiotic signaling as from mere colonization or competitive exclusion (539)

and more recently, metabolic-dysfunction associated steatohepatitis (MASH)