However, carbonation, caffeine, or personal responses to sweeteners may affect feelings of hunger or fullness in some individuals
These foods support hormone production, brain function, and absorption of fat-soluble vitamins, all of which are important during active weight loss
Importantly, these mechanistic hypotheses are supported by evidence from large, randomised controlled trials, which has demonstrated that GLP-1RAs reduced major adverse cardiovascular events (MACE), including myocardial infarction, stroke and cardiovascular death, particularly in high-risk individuals such as those with type 2 diabetes mellitus
Therefore, we recommend that companies determine their regulatory pathway to market in 2025-2026 and consider pre-subs in 2026 to allow time to take action on any FDA feedback before submitting the premarket submission