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Please see also the XGBoost documentation for additional information on model parameters ( SHapley additive exPlanations (SHAP) analysis We interpreted our ML models and assigned relative importance to variables influencing circulating TMAO levels by co-opting SHAP values, as expanded for tree-based ML models 28 and recently used to objectively evaluate factors driving metabolite plasma levels in humans 23

L-carnitine plays an important role in maintaining metabolic flexibility in the human body

The authors of the 2025 study from the University of Turin suggest that the combination of L-carnitine and selenium may have a synergistic effect, and that L-carnitine may also have an immunomodulatory role, and its actions are not limited to peripheral thyroid hormone antagonism

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