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This loss of immune ignorance may also rely on other IFN-induced pathways of alternative antigen formation 14,17 , e.g., post-translation modifications (PTMs), alternative transcription start sites generating an INS defective ribosomal product (DRiP) 18 and peptide cis -splicing, i.e., the fusion of non-contiguous protein fragments

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However, using a degraded peptide means dosing becomes unpredictable, since you cannot know how much active compound remains