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10.1016/j.jconrel.2011.05.024 12 BourgeauxV.AufradetE.CampionY.De SouzaG.HorandF.BessaadA.et al (2012)

As a result, the balance between cell proliferation and apoptosis is disrupted, contributing to gastric carcinogenesis ( waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Figure 3)

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Shown to be effective for chronic diseases such as MS, Alzheimers, Parkinsons, long-haul COVID, and vaccine injuries, it also improves cognition, mood, mental clarity, and can support weight loss