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An overexpression of GPx3 in cumulus cells may indicate a poor implantation of the embryo [23], because the GPx3 overexpression is connected with the production of ROS in oocytes and cumulus cells [13]

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Particularly the pyruvate dehydrogenase kinase isoenzyme-4 gene encodes PDK that converts pyruvate, CoA and oxidized nicotinamide adenine dinucleotide (NAD+) into acetyl-CoA, the reduced form of nicotinamide adenine dinucleotide (NADH) and carbon dioxide