has also served as a consultant for Actelion, Amgen, Aria, Axon Therapies, BD Biosciences, Boehringer Ingelheim, Cytokinetics, Edwards Lifesciences, Eli Lilly, Imbria, Janssen, Merck, Novo Nordisk, NGM Biopharmaceuticals, NXT and VADovations and is named as an inventor (US patent no
Dapagliflozin Initial Combination Therapy with Metformin HCl Extended-Release A total of 1236 treatment-naive adult patients with inadequately controlled type 2 diabetes mellitus (HbA1c 7.5% and 12%) participated in 2 active-controlled trials of 24-week duration to evaluate initial therapy with dapagliflozin 5 mg (NCT00643851) or 10 mg (NCT00859898) in combination with metformin extended-release formulation
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found that GLP-1-based therapies, including exenatide or sitagliptin, could significantly lower BP in the same manner as insulin therapy (121), thus suggesting that the hypotensive effects of insulin may be associated with GLP-1 (122)