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Note that the IDPs/IDRs are fuzzy by default, as they exist as highly dynamic conformational ensembles

Melissa officinalis exhibits strong antioxidant properties, regulates lipid metabolism (Petrisor et al., 2022), and can also inhibit ferroptosis (Mousa et al., 2022), while ferroptosis exerts a significant pro-inflammatory effect

All in all, astrocytic responses in AD are complex and disease stage-specific: in the early, compensated phase of AD (manifested by mild cognitive impairment) astrocytes, together with other neuroglia become reactive and arguably protect brain tissue