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The rising prevalence of IBD worldwide and the ageing of the IBD population will likely increase the number of patients with metabolic comorbidities who may potentially benefit from a combination treatment with GLP-1 RAs

Glecaprevir (GLE) is an HCV NS3/4A protease inhibitor that has pangenotypic antiviral activity, with half-maximal effective concentration values 5 nanomolar across all major HCV GTs.[16] Pibrentasvir (PIB) is a novel pangenotypic NS5A inhibitor with half-maximal effective concentration values of 1,000 IU/mL at screening

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So P53 may act on reactive oxygen species (ROS)-induced stress through lipoxygenase [19]