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Complex formulations that are difficult to replicate controlled-release systems, transdermal patches, sterile injectables can delay generic entry by 12 to 24 months beyond compound patent expiry, because generic companies need time to demonstrate bioequivalence through clinical studies

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These three Herpesviridae pathways were present in the DM2-AD comorbidity network, allowing us to explore potential indirect mechanisms through which Metformin may influence viral-associated pathways linked to AD risk