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Heavy metals such as bismuth, lead, copper, arsenic, gold, copper, cobalt, chromium, silver, mercury, and magnesium can induce the development of a bluish-black line, the so-called Burtons line, along the gingival margin, the thickness of which is proportional to the extent of gingival inflammation [31]

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Researchers can review our in vitro epithalon dosage guide for standardized preparation parameters and solubility best practices

Some adverse effects reported were irritation of nasal passages, headaches, and a bloody nose