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The VPA-exposed group exhibited activated microglia characterized by hypertrophic morphology with significantly elevated Iba1 fluorescence intensity compared to the control group (P 0.05)
That is roughly double what semaglutide produces
Two major pathways dominate
Cardiovascular outcomes, long-term efficacy and safety In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits [109]
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