Appropriate reasons to discuss discontinuation include achieving your weight loss goals and wanting to attempt weight maintenance without medication, experiencing intolerable side effects that don't improve with dose adjustment or supportive management, financial constraints that make continued treatment unsustainable, planning pregnancy (semaglutide is not recommended during pregnancy and should be discontinued at least two months before conception), or developing contraindications to continued use
For a subset of individuals, particularly those who are already sensitive to heart rate changes, it becomes noticeable
In both the Asian and non-Asian patients subgroups, oral semaglutide 3, 7, and 14 mg was more effective in reducing HbA1c than placebo, and between-subgroups analysis showed that semaglutide 3, 7, and 14 mg was more effective in reducing HbA1c in the Asian patients subgroup than in the non-Asian patients subgroup
However, certain medical conditions require specific precautions
