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In this regard, GLP-1 treatment leads to decreased expression of macrophagespecific markers for M1 (inducible NOS (iNOS), IL6 and TNF) and enhances expression level of M2-marker genes, including arginine1, macrophage galectin-1 (MGL-1), IL10, as well as mannose receptor-1 (MRC-1)
The question that matters clinically is whether a given patient is a good candidate, what the right protocol looks like for their specific goals and lab results, and whether they have access to a supervised framework that can catch the small number of patients for whom these compounds are not appropriate before they start rather than after
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