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Among anaerobic fermentation products, acetate, propionate, and butyrate are the predominant SCFAs, with a molar ratio of approximately 60:20:20 ( Butyrate, serving as the primary energy source for colonocytes, possesses multiple functions including maintaining intestinal barrier integrity, modulating immune responses, and suppressing inflammation ( Protein metabolism: in modern diets, the quantity of protein entering the colon is approximately equivalent to that of carbohydrates ( Tryptophan, an essential amino acid, is metabolized by gut bacteria to produce indole and indole derivatives that serve as aryl hydrocarbon receptor (AhR) ligands, participating in the regulation of intestinal barrier function and immune homeostasis ( Fat metabolism: dietary fat primarily comprises triglycerides, with minor amounts of phospholipids, sphingolipids, and cholesterol

It doesnt replace GH

According to the GRADE system, the overall level of certainty of the evidence in this meta-analysis was high and moderate (Table 2)

Ohmoto, A