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While the 28-day treatment period and use of only male rats were consistent with standard protocols to reduce variability in early-phase toxicological studies, these choices limit the extrapolation of our findings to chronic exposure scenarios and across sexes

However, NAC must be administered within a narrow window of time after an overdose to be most effective

Hermansen K, Bkdal TA, Dring M, Pietraszek A, Mortensen LS, Jrgensen H, Flint A: Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, cross-over trial

Diabetes Care 42(Suppl 1):S46S60