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Although Compounds 1.62 and 1.63 lost the efficacy for a major detoxification process of GSH by being unable to interact with the GST enzyme, this does not indicate a loss for all the detoxification pathways
Oxidation of either methionine 351 or methionine 358 in alpha-1 antitrypsin causes loss of anti-neutrophil elastase activity
They can undergo gradual degradation to enable the sustained release of bioactive ions, which exert multiple functions, including interference with tumor cell metabolism and immune regulation
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