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Induction of cystine transport via system xc and maintenance of intracellular glutathione levels in pancreatic acinar and islet cell lines

What they found: Prevention of age-related changes in gene expression , NMN-treated mice had an expression profile closer to young mice Restoration of mitochondrial function in multiple tissues Improvement of insulin sensitivity of 35 to 50 % Preserved muscle strength and endurance Preserved bone density Better vision (NMN-treated mice had a slower decline in ophthalmologic parameters) No serious adverse effects Why it matters: This is the most ambitious preclinical study of NMN/NAD+ in animal aging models

14,15 As the understanding of -cell biology advances, a combination of stem cell therapy and gene editing presents promising prospects for diabetes treatment, although further evaluation is needed to determine long-term efficacy and safety

Helps to treat anorexia