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Sodium-glucose cotransporter 2 inhibitor ameliorates high fat diet-induced hypothalamic-pituitary-ovarian axis disorders

However, which signaling pathway produces the unwanted side effects (such as respiratory suppression and constipation) is currently controversial: one view is that it is caused by -arrestin signal transduction, and the other view suggests that the respiratory depression by opioids is caused due to G protein-gated inwardly rectifying potassium (GIRK) channel signaling

Additionally, activated GPER may increase glucose and lipid metabolism in osteoblasts, thereby improving the activity and function of bone cells [110, 149, 150]

[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Tang X., Yang J., Li J