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Furthermore, pre-synaptic and post-synaptic proteins, synaptophysin and PSD-95, which reflect synaptic disruption [122], were upregulated, neuronal excitability normalized, and intracellular calcium, a key regulator in metabolic dysfunction and progressive neuronal loss [123], was modulated [121]

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Influence of amino acid availability on protein turnover in perfused skeletal muscle .Biochimica et Biophysica Acta , 544 (2), 351-359