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Indeed, while enhanced GLP-1R signaling outside of the islet may mediate, at least in part, the in vivo effects of GLP-1R agonists on enhanced islet function, studies performed in isolated islets, in the absence of peripheral GLP-1R signaling, confirm the propensity for GLP-1R agonists to induce direct intra-islet effects ( Figure 4 )

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Overexpression of IGF-1 in muscles leads to an increase in muscle size

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Ne remplace pas une alimentation quilibre

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Brain 134 , 9871002 (2011)

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