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This matters because insulin resistance impairs hormone-sensitive lipase (HSL), the enzyme that liberates fatty acids from triglyceride stores in fat cells

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However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy

Chemically, Ipamorelin is a pentapeptide (five amino acids long) that mimics the action of ghrelin , the bodys hunger hormone, by binding to the GHS-R1a receptor in the pituitary gland