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2023;18(8):e0289616

In line with strong and stable interactions of His1-Ala2 of GLP-1 compared with transient interactions of His1-Gly2 in exendin-4, truncation of these two N-terminal residues reduces GLP-1 affinity by 100-300 fold, whereas for exendin-4, this has no effect, albeit for both peptides, these residues are required for GLP-1R-mediated cAMP production 2225

Its ability to neutralize the free radicals, enhance the immune function, and support liver function

Manufacturers specify shelf life at -20C ranging from 12 to 24 months, though peptides stored under these conditions often retain activity beyond labeled expiration if the seal remains intact