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In normal cells, FOXO4 binds to p53 and sequesters it in the nucleus

Iranmanesh, A

An emerging concept is that some agonists such as DAMGO regulate MOR by selectively engaging GRK-arrestin mechanisms, while others such as morphine selectively engage non-GRK-arrestin mechanisms

however, the wild-type mice under the same conditions exhibit a massive increase in plasma GH and hepatic autophagy, suggesting the positive connection between the plasma GH and hepatic autophagy (Zhang et al., 2015)