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Dynamics of peptide-TMD interactions are correlated with the allosteric effect of G proteins on agonist affinity and G protein conformation The stark contrast in the requirement for stable TMD interactions for exendin-P5 affinity relative to GLP-1, oxyntomodulin and exendin-4, raises important questions regarding molecular mechanisms for peptide binding and receptor activation

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Elevated serum VitD promotes calcium deposition in bone