They may include: nausea, vomiting, diarrhea, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distention, eructation (burping), hypoglycemia in patients with diabetes, flatulence, gastroenteritis, gastroesophageal reflux disease, and nasopharyngitis
This effect occurs through multiple pathways: decreased body weight reduces mechanical strain on arteries, GLP-1 signaling relaxes blood vessel walls, and the medication lowers inflammation markers linked to hypertension
Retatrutide has not been studied in lactating women, and the mechanism of action raises concerns about potential transfer to breast milk and effects on infant development
Standard dosing is 500mg two to three times daily with meals