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Cases of medullary thyroid carcinoma (MTC) have been reported with other drugs in the same class, but a direct causal relationship in humans has not been established

[28] Oxytocin binds to the G-protein-coupled oxytocin receptor (OXTR), activating phospholipase C, increasing intracellular calcium, and triggering downstream MAP-kinase and PI3-kinase cascades

Overweight or obesity was defined as having 1 diagnosis during the study period based on International Classification of Diseases, Tenth Revision, Clinical Modification (ICD10CM) codes or recorded laboratory measurements indicating body mass index (BMI) 27.0 kg/m 2