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It also advises against vitamin E for the prevention of cardiovascular disease and cancer, and warns of the potential risks of vitamin or mineral supplementation in general, recommending instead a healthy, balanced diet.78 The risks and benefits of systemic skin aging treatments must be carefully weighed up, as their purpose is to reverse or slow down a natural process rather than treat a particular disease

TL;DR (Summary) ~15% reduction in visceral fat Minimal change in subcutaneous fat No major safety signal in randomized controlled trials This is one of the few interventions shown to selectively reduce visceral fat in humans

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