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Beyond interaction with lipid enzymes, our MS interactome analysis indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 90 , suggesting a prominent role for the receptor in the control of intra-organelle ion homoeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 91
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The requirements for vitamin B 12 intake in pregnancy set by most official authorities are based on the recommendations for adults with an increment (0205 g/d) to compensate for B 12 accumulated by the fetus (7274)
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