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We believe that GLP-1 and BMS21 share the same binding site in the GLP-1R TM domain given their high sequence identity (7 identical of out 11 residues)

Geneva: 2020

Quantification of inflammatory and degradation marker Total mouse PGE 2 , IL-6, MMP-3, and MMP-13 concentration of primary murine chondrocytes (p0) or murine macrophage cell line (p + 9) after 24 h of treatment was assayed in cell-free supernatants using an ELISA kit, according to the manufacturers instructions

This tolerogenic behavior of DCs was ubiquitous across different mouse strains and occurred independently of / T cells (Oertli et al., 2013)