This is especially true when the blood sugar level changes
Clinical trials show semaglutide reduces systolic blood pressure by around 3.5-5 mmHg compared to placebo, likely due to weight loss and direct metabolic effects
Tirzepatide and semaglutide shared similar rates for nausea, diarrhea, abdominal pain, and dyspepsia , but semaglutide had higher rates of vomiting, constipation, and GERD
Semaglutide, GLP-1 Drugs, and IBS: Managing Side Effects and Gut Health Aleks Jagiello BSc, MSc, RD Sep 11, 2025 17 min read Glucagon-like peptide-1 (GLP-1) receptor agonist medications, such as semaglutide (brand names Wegovy, Ozempic ), have surged in popularity for weight loss and type 2 diabetes management