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Mitochondrial respiratory chain complex 1 is targeted by metformin and its inhibition is involved in AMP-activated protein kinase-independent regulation of hepatic gluconeogenesis by triggering alterations in cellular energy charge and redox state

This helps restore the chain's efficiency and boost ATP production, especially in cells under high metabolic demand, like neurons

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April 2024 Landmark Research Framework The April 3, 2024 paper by Predrag Sikiric and 21 colleagues from the University of Zagreb represents the most comprehensive synthesis to date of BPC-157s neurological effects