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Its induction exerts direct tumor-suppressive effects through iron-mediated oxidative damage, yet paradoxically drives pro-tumorigenic adaptations in the tumor microenvironment (TME), particularly in advanced PCa with dysregulated iron metabolism [66,67]
Shahraki, O., Shayganpour, M., Hashemzaei, M., & Daneshmand, S
High-frequency sleep fragmentation in obstructive sleep apnea has been shown to induce outcomes similar to chronic sleep deprivation, including reduced antioxidant enzyme activity (e.g., superoxide dismutase, glutathione peroxidase), aberrant mitochondrial morphology, and diminished ATP production, all of which impair neuronal metabolism ( 5 Sleep and mitochondrial health affect peripheral systems including the immune system and gut 5.1 Mitochondrial decline, inflammaging, and sleep The concept of inflammaging, first introduced by Claudio Franceschi in 2000, refers to the chronic, low-grade systemic inflammation that characterizes biological aging (Li et al., 2021
Smith, and T.M
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