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Reducing Risk of Heart and Kidney Disease: Lowers the likelihood of cardiovascular and renal complications

(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents

While both compounds drive appetite suppression and insulin sensitization through GLP-1 and GIP pathways, Retatrutides GCGR activity delivers three additional effects: direct hepatic fat mobilization, increased thermogenesis, and accelerated lipid oxidation