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In summary, chronic exposure of high concentrations of LC-FFA induce widespread transcriptional changes which are deleterious to -cell viability, identity, and function

Studies have suggested that higher doses might become necessary for significant health advantages, but they should be taken under medical supervision

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Enzymes such as urease and catalase can lose up to 50% of their potency after shaking, fibrinogen clotting activity is decreased after shear stress, and recombinant IL-2 and recombinant interferon activity is substantially affected by aggregation from shaking and shearing (2)