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Besides, the effects of berberine in Alzheimers mice may be related to the inhibition of NF-B activity and lipid peroxidation, and the increase of glutathione activity in the hippocampus (He et al., 2017) (Figure 2)

Tachyphylaxis is contingent upon a full 24-hour exposure, as evidenced by a study in which rats treated with liraglutide (with half-life of 11 15 hours) twice daily for 14 days had markedly diminished gastric emptying while those treated with exenatide (with half-life of 2 3 hours) twice daily over the same period still displayed a profound reduction in gastric emptying, although both compounds had similar effects on body weight reduction (158)

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