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This neural feedback stimulates efferent vagal fibers, which produce acetylcholine, which binds to 7 nicotinic acetylcholine receptors (7nAChR) on macrophages and immune cells, inhibiting pro-inflammatory cytokine production [120]

Unlike traditional approaches that target the vascular system, PT-141 acts centrally via the nervous system, specifically activating MC3R and MC4R receptors, to study the neurological pathways of sexual arousal and function

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