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CrossRef Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis Cong Liu, Milena Schnke, Enchen Zhou, Zhuang Li, Sander Kooijman, Maritte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen Cardiovascular Research.2022

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For instance, targeting glutamine synthetase (GS), the enzyme that catalyzes the conversion of glutamate to glutamine, represents an alternative strategy to perturb glutamine homeostasis within cancer cells [67]

In addition to its antidiabetic results, it was also found to achieve cardiac protection by activating the AMPK pathway [225]