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Adjunct Lifestyle Modification, Dietary and Physical Activity Lifestyle modification, dietary and physical activity are considered first-line interventions for people with T2D [41, 63, 65]

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Interestingly, Ogg1 activity significantly decreases with age in neuronal extracts from rat brains, and APE1 is reduced in neurons and astrocytes from the frontal and parietal cortex of old rats (Kisby et al., 2010

The fluorescent detection of DCFH-DA revealed the reversal of Erastin-induced increases in intracellular ROS levels after pre-processing with QCT (Fig