By shrinking the period between doses, we can see that the peaks and troughs, as we would expect, have reduced in amplitude
Oral Dosing Runs Higher Injectable: 200 to 500mcg per dose Oral: 500 to 1,000mcg per dose, once or twice daily, taken on an empty stomach Higher oral doses are used to make up for the fact that the gut absorbs the compound poorly compared to injections
Though with similar effects as some pre-existing drugs (semaglutide, liraglutide, exenatide, etc.) targeting diabetes and obesity, tirzepatide is considered a first-in-class medication for demonstrating action on both the glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors
Compared to those who stayed on treatment, their: Heart risk rose 4% after 6 months It increased 14% after 1 year Heart risk climbed 22% after 2 years By that point, the earlier heart benefits were nearly gone