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In agreement with expectations, the first outcome trial of a GLP-1RA, the ELIXA trial of the short-acting lixisenatide, an exendin-4 derivative with properties almost identical to those of exendin-4 or exenatide (stable, full agonists of the GLP-1 receptor), showed no increased cardiovascular risk in a patient group with severely increased CVD risk

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Some of the side effects we found like nausea are well known and that shows that the method is picking up a real signal, said Dr Sharath Chandra Guntuku, research associate professor in computer and information science at the University of Pennsylvania and senior author of the study

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